B12 Eksikliğine Bağlı Ensefalopati
PDF
Cite
Share
Request
Invited Review
VOLUME: 11 ISSUE: 1
P: 67 - 72
April 2023

B12 Eksikliğine Bağlı Ensefalopati

Turk Radiol Semin 2023;11(1):67-72
1. İstanbul Medipol Mega Üniversite Hastanesi, Radyoloji Anabilim Dalı, İstanbul Türkiye
2. Ankara Etlik Şehir Hastanesi, Radyoloji Kliniği, Ankara, Türkiye
No information available.
No information available
PDF
Cite
Share
Request

ABSTRACT

Vitamin B12, eritropoez, miyelin formasyonu ve biyokimyasal metabolizma için gerekli bir vitamindir. Eksikliğinde beyin, optik sinirler, periferik sinirler ve spinal kord etkilenebilir. Beyin ve özellikle spinal kordda oluşan demiyelinizasyon ve aksonal dejenerasyonun, hastalarda non-spesifik semptomlara yol açabilmesi nedeniyle vitamin B12 eksikliğinde beyinde ve spinal kordda görülebilen tipik “manyetik rezonans görüntüleme” bulgularının bilinmesi erken tanı ve böylece kalıcı hasarları önleyebilmek adına oldukça önem taşır.

Keywords:
Manyetik rezonans görüntüleme, subakut kombine dejenerasyon, vitamin B12 eksikliği

References

1
Ralapanawa DM, Jayawickreme KP, Ekanayake EM, Jayalath WA. B12 deficiency with neurological manifestations in the absence of anaemia. BMC Res Notes 2015; 8: 458. [CrossRef]
2
Ravina B, Loevner LA, Bank W. MR findings in subacute combined degeneration of the spinal cord: a case of reversible cervical myelopathy. AJR Am J Roentgenol 2000; 174: 863-5. [CrossRef]
3
Dror DK, Allen LH. Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms. Nutr Rev 2008; 66: 250-5. [CrossRef]
4
Ozyurek H, Ceyhan M, Ince H, Aydın OF. Vitamin B12 deficiency as a treatable cause ofsevere brain atrophy. Neurology Asia 2021; 26: 187-91. [CrossRef]
5
Briani C, Dalla Torre C, Citton V, Manara R, Pompanin S, Binotto G, et al. Cobalamin deficiency: clinical picture and radiological findings. Nutrients 2013; 5: 4521-39. [CrossRef]
6
Miller JW. Proton pump inhibitors, H2-receptor antagonists, metformin, and vitamin B-12 deficiency: clinical implications. Adv Nutr 2018; 9: 511S-8S. [CrossRef]
7
Korenke GC, Hunneman DH, Eber S, Hanefeld F. Severe encephalopathy with epilepsy in an infant caused by subclinical maternal pernicious anaemia: case report and review of the literature. Eur J Pediatr 2004; 163: 196-201. [CrossRef]
8
Tangney CC, Aggarwal NT, Li H, Wilson RS, Decarli C, Evans DA, et al. Vitamin B12, cognition, and brain MRI measures: a cross-sectional examination. Neurology 2011; 77: 1276-82. [CrossRef]
9
Serin HM, Arslan EA. Neurological symptoms of vitamin B12 deficiency: analysis of pediatric patients. Acta Clin Croat 2019; 58: 295-302. [CrossRef]
10
Jain KK, Malhotra HS, Garg RK, Gupta PK, Roy B, Gupta RK. Prevalence of MR imaging abnormalities in vitamin B12 deficiency patients presenting with clinical features of subacute combined degeneration of the spinal cord. J Neurol Sci 2014; 342: 162-6. [CrossRef]
11
Garg D, George JA, Dhamija RK. Of dots and levels: a case of partial subacute combined degeneration. Trop Doct 2020; 50: 367-8. [CrossRef]
12
Zhang HN, Wang L, Sun L, Yang Y. Three-point sign in subacute combined degeneration of the spinal cord: a case report. Medicine (Baltimore) 2018; 97: e11620. [CrossRef]
13
Goodman BP, Chong BW, Patel AC, Fletcher GP, Smith BE. Copper deficiency myeloneuropathy resembling B12 deficiency: partial resolution of MR imaging findings with copper supplementation. AJNR Am J Neuroradiol 2006; 27: 2112-4. [CrossRef]