ABSTRACT
Diffuse liver diseases represent a heterogeneous group of disorders characterized by diffuse involvement of the hepatic parenchyma and may result from metabolic, inflammatory, vascular, cholestatic, or infiltrative etiologies. This review summarizes the etiologic classification and pathophysiologic background of diffuse liver diseases and discusses the imaging findings of common entities such as hepatic steatosis, fibrosis, and cirrhosis using ultrasound, computed tomography, and magnetic resonance (MR) imaging. Particular emphasis is placed on emerging quantitative imaging biomarkers, including MR imaging-based proton density fat fraction and ultrasound- and MRI-based elastography techniques, highlighting their clinical applications and limitations. In addition, imaging features of nodular lesions in chronic liver disease, vascular disorders, cholestatic diseases, and infiltrative metastatic patterns are reviewed. The central role of imaging in disease characterization, staging, detection of complications, and patient management is emphasized.
Keywords:
Diffuse liver disease, steatosis, fibrosis, elastography, MRI, PDFF
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