Pediatric-only Liver Lesions
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Review
VOLUME: 14 ISSUE: 1
P: 157 - 171
April 2026

Pediatric-only Liver Lesions

Turk Radiol Semin 2026;14(1):157-171
1. Hacettepe Üniversitesi Tıp Fakültesi Radyoloji Anabilim Dalı, Ankara Türkiye
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No information available
Received Date: 11.03.2026
Accepted Date: 20.04.2026
Online Date: 27.04.2026
Publish Date: 27.04.2026
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ABSTRACT

Evaluation of pediatric liver lesions differs fundamentally from that in adults and requires a thorough, systematic approach that accounts for anatomical variations, congenital anomalies, and age-specific lesion profiles. Accurate diagnosis relies not only on imaging findings but also on clinical context, including pre-existing conditions, risk factors, and serum alpha-fetoprotein levels. Ultrasonography is the first-line imaging modality due to its wide availability and lack of ionizing radiation. Computed tomography and magnetic resonance imaging provide high-resolution characterization of lesion architecture, enhancement patterns, and overall hepatic anatomy. The PRE-TEXT system is commonly used to stage primary malignant pediatric liver tumors. It considers the number of involved hepatic segments and the tumor’s relationship to critical structures to guide surgical planning. Together with the POST-TEXT system used in post-operative follow-up, it serves as an important prognostic indicator for overall survival.

Keywords:
Liver imaging, children, ultrasonography, computed tomography, magnetic resonance imaging

References

1
Rozell JM, Catanzano T, Polansky SM, Rakita D, Fox L. Primary liver tumors in pediatric patients: proper imaging technique for diagnosis and staging. Semin Ultrasound CT MR. 2014; 35: 382-93.
2
Meyers RL. Tumors of the liver in children. Surg Oncol. 2007; 16: 195-203.
3
Sintusek P, Phewplung T, Sanpavat A, Poovorawan Y. Liver tumors in children with chronic liver diseases. World J Gastrointest Oncol. 2021; 13: 1680-95.
4
Chiorean L, Cui XW, Tannapfel A, Franke D, Stenzel M, Kosiak W, et al. Benign liver tumors in pediatric patients - review with emphasis on imaging features. World J Gastroenterol. 2015; 21: 8541-61.
5
Dong Y, Cekuolis A, Schreiber-Dietrich D, Augustiniene R, Schwarz S, Möller K, et al. Review on pediatric malignant focal liver lesions with imaging evaluation: part II. Diagnostics (Basel). 2023; 13: 3659.
6
Khanna G, Chavhan GB, Schooler GR, Fraum TJ, Alazraki AL, Squires JH, et al. Diagnostic performance of LI-RADS version 2018 for evaluation of pediatric hepatocellular carcinoma. Radiology. 2021; 299: 190-9.
7
Towbin AJ, Meyers RL, Woodley H, Miyazaki O, Weldon CB, Morland B, et al. 2017 PRETEXT: radiologic staging system for primary hepatic malignancies of childhood revised for the paediatric hepatic international tumour trial (PHITT). Pediatr Radiol. 2018; 48: 536-54.
8
Meyers RL, Maibach R, Hiyama E, Häberle B, Krailo M, Rangaswami A, et al. Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children’s Hepatic tumors International Collaboration. Lancet Oncol. 2017; 18: 122-31.
9
Lee S, Jeon H, Han J, Song IK, Baek SH, Shim S, et al. Management of neonatal hepatic hemangiomas: a single-center experience focused on challenging cases. J Clin Med. 2024; 13: 2839.
10
Estefanía-Fernández K, Triana P, Ramírez-Amorós C, Gaspar-Pérez M, Muñoz-Serrano AJ, Velayos M, et al. Non-involuting congenital hepatic hemangioma: lessons from a case series. Children (Basel). 2025; 12: 893.
11
Gnarra M, Behr G, Kitajewski A, Wu JK, Anupindi SA, Shawber CJ, et al. History of the infantile hepatic hemangioma: from imaging to generating a differential diagnosis. World J Clin Pediatr. 2016; 5: 273-80.
12
Darbari A, Sabin KM, Shapiro CN, Schwarz KB. Epidemiology of primary hepatic malignancies in U.S. children. Hepatology. 2003; 38: 560-6.
13
Spector LG, Birch J. The epidemiology of hepatoblastoma. Pediatr Blood Cancer. 2012; 59: 776-9.
14
Yhoshu E, Lone YA, Mahajan JK, Singh UB. Hepatoblastoma with precocious puberty. J Indian Assoc Pediatr Surg. 2019; 24: 68-71.
15
De Ioris M, Brugieres L, Zimmermann A, Keeling J, Brock P, Maibach R, et al. Hepatoblastoma with a low serum alpha-fetoprotein level at diagnosis: the SIOPEL group experience. Eur J Cancer. 2008; 44: 545-50.
16
Woodward PJ, Sohaey R, Kennedy A, Koeller KK. From the archives of the AFIP: a comprehensive review of fetal tumors with pathologic correlation. Radiographics. 2005; 2: 215-42.
17
Chung EM, Lattin GE Jr, Cube R, Lewis RB, Marichal-Hernández C, Shawhan R, et al. From the archives of the AFIP: pediatric liver masses: radiologic-pathologic correlation. Part 2. Malignant tumors. Radiographics. 2011; 31: 483-507.
18
Pan FS, Xu M, Wang W, Zhou LY, Xie XY. Infantile hepatic hemangioendothelioma in comparison with hepatoblastoma in children: clinical and ultrasound features. Hepat Mon. 2013; 13: e11103.
19
Jha P, Chawla SC, Tavri S, Patel C, Gooding C, Daldrup-Link H. Pediatric liver tumors--a pictorial review. Eur Radiol. 2009; 19: 209-19.
20
Sharma K, Agarwala S, Kandasamy D, Jana M, Sharma R, Dhua A, et al. Role of diffusion weighted MRI (DW-MR) in detection of satellite lesions not detected with multiphase CT scans in hepatoblastoma and its implications for management. Indian J Pediatr. 2022; 89: 968-74.
21
Ismail H, Dembowska-Bagińska B, Broniszczak D, Kaliciński P, Maruszewski P, Kluge P, et al. Treatment of undifferentiated embryonal sarcoma of the liver in children--single center experience. J Pediatr Surg. 2013; 48: 2202-6.
22
López-Terrada D, Alaggio R, de Dávila MT, Czauderna P, Hiyama E, Katzenstein H, et al. Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG Liver Tumors Symposium. Mod Pathol. 2014; 27: 472-91.
23
Shi Y, Rojas Y, Zhang W, Beierle EA, Doski JJ, Goldfarb M, et al. Characteristics and outcomes in children with undifferentiated embryonal sarcoma of the liver: a report from the National Cancer Database. Pediatr Blood Cancer. 2017; 64: e26272.
24
Putra J, Ornvold K. Undifferentiated embryonal sarcoma of the liver: a concise review. Archives of Pathology & Laboratory Medicine. 2015; 139: 269-73.
25
Ros PR, Olmsted WW, Dachman AH, Goodman ZD, Ishak KG, Hartman DS. Undifferentiated (embryonal) sarcoma of the liver: radiologic-pathologic correlation. Radiology. 1986; 161: 141-5.
26
Gabor F, Franchi-Abella S, Merli L, Adamsbaum C, Pariente D. Imaging features of undifferentiated embryonal sarcoma of the liver: a series of 15 children. Pediatr Radiol. 2016; 46: 1694-704.
27
Yoon W, Kim JK, Kang HK. Hepatic undifferentiated embryonal sarcoma: MR findings. J Comput Assist Tomogr. 1997; 21: 100-2.
28
Das CJ, Dhingra S, Gupta AK, Iyer V, Agarwala S. Imaging of paediatric liver tumours with pathological correlation. Clinical Radiology. 2009; 64: 1015-25.
29
Martin DR, Danrad R, Hussain SM. MR imaging of the liver. Radiol Clin North Am. 2005; 43: 861-86, viii.
30
LeGout JD, Bolan CW, Bowman AW, Caserta MP, Chen FK, Cox KL, et al. Focal nodular hyperplasia and focal nodular hyperplasia-like lesions. Radiographics. 2022; 42: 1043-61.
31
Gore RM, Pickhardt PJ, Mortele KJ, Fishman EK, Horowitz JM, Fimmel CJ, et al. Management of incidental liver lesions on CT: a white paper of the ACR incidental findings committee. J Am Coll Radiol. 2017; 14: 1429-37.
32
Strobel D, Seitz K, Blank W, Schuler A, Dietrich CF, von Herbay A, et al. Tumor-specific vascularization pattern of liver metastasis, hepatocellular carcinoma, hemangioma and focal nodular hyperplasia in the differential diagnosis of 1,349 liver lesions in contrast-enhanced ultrasound (CEUS). Ultraschall Med. 2009; 30: 376-82.
33
Lee YH, Kim SH, Cho MY, Shim KY, Kim MS. Focal nodular hyperplasia-like nodules in alcoholic liver cirrhosis: radiologic-pathologic correlation. AJR Am J Roentgenol. 2007; 188: W459-63.
34
Van Wettere M, Purcell Y, Bruno O, Payancé A, Plessier A, Rautou PE, et al. Low specificity of washout to diagnose hepatocellular carcinoma in nodules showing arterial hyperenhancement in patients with Budd-Chiari syndrome. J Hepatol. 2019; 70: 1123-32.
35
Egbe AC, Poterucha JT, Warnes CA, Connolly HM, Baskar S, Ginde S, et al. Hepatocellular carcinoma after fontan operation: multicenter case series. Circulation. 2018; 138: 746-8.
36
Özcan HN, Karçaaltıncaba M, Seber T, Yalçın B, Oğuz B, Akyüz C, et al. Hepatocyte-specific contrast-enhanced MRI findings of focal nodular hyperplasia-like nodules in the liver following chemotherapy in pediatric cancer patients. Diagn Interv Radiol. 2020; 26: 370-6.
37
Esparza Estaún J, González Alfageme A, Sáenz Bañuelos J. Radiological appearance of diaphragmatic mesothelial cysts. Pediatric Radiology. 2023; 33: 855-8.
38
Madhusudhan KS, Vyas S, Sharma S, Srivastava DN, Gupta AK. Portal vein abnormalities: an imaging review. Clinical Imaging. 2018; 52: 70-8.
39
Morgan G, Superina R. Congenital absence of the portal vein: two cases and a proposed classification system for portasystemic vascular anomalies. Journal of Pediatric Surgery. 1994; 29: 1239-41.
40
Stringer MD. The clinical anatomy of congenital portosystemic venous shunts. Clin Anat. 2008; 21: 147-57.
41
White CS, Baffa JM, Haney PJ, Pace ME, Campbell AB. MR imaging of congenital anomalies of the thoracic veinss. RadioGraphics. 1997; 17: 595-608.
42
Karamlou T, Gurofsky R, Al Sukhni E, Coles JG, Williams WG, Caldarone CA, et al. Factors associated with mortality and reoperation in 377 children with total anomalous pulmonary venous connection. Circulation. 2007; 115: 1591-8.
43
Dillman JR, Yarram SG, Hernandez RJ. Imaging of pulmonary venous developmental anomalies. AJR Am J Roentgenol. 2009; 192: 1272-85.
44
Michel F, Brevaut-Malaty V, Pasquali R, Thomachot L, Vialet R, Hassid S, et al. Comparison of ultrasound and X-ray in determining the position of umbilical venous catheters. Resuscitation. 2012; 83: 705-9.
45
Kim MJ, Yoo SY, Jeon TY, Kim JH, Kim YJ. Imaging of umbilical venous catheter-related hepatic complications in neonates. J Korean Soc Radiol. 2023; 84: 586-95.
46
Derinkuyu BE, Boyunaga OL, Damar C, Unal S, Ergenekon E, Alimli AG, et al. Hepatic complications of umbilical venous catheters in the neonatal period: the ultrasound spectrum. J Ultrasound Med. 2018; 37: 1335-44.