Abstract
Thyroid imaging-radiological evaluation is based on ultrasound (US). Computed tomography and magnetic resonance imaging are rarely needed. To be able to differentiate the rare malignant nodules among the frequent benign nodules, the sonographic clues should be carefully evaluated and interpreted. The clinical and laboratory findings are usually normal in thyroid cancer patients. After detailed description of the nodules, their risk of malignancy should be given by (American Thyroid Association Guidelines) or thyroid imaging reporting and data systems (TI-RADS) terminology defined by several societies of USA, Korea, and Europe basically. These risk stratification systems, which have an increasing popularity in the last 15 years, allow everyone to talk the same language. Some nodules will be biopsied and diagnosed as thyroid cancer, based on these TI-RADS. Thyroid cancer has 4 basic types; papillary, follicular, medullary and anaplastic.
Keywords: Thyroid, ultrasound, thyroid nodule, thyroid cancer, TI-RADS
References
Tessler FN, Middleton WD, Grant EG, Hoang JK, Berland LL, Teefey SA, et al. ACR thyroid imaging, reporting and data system (TI-RADS): white paper of the ACR TI-RADS committee. J Am Coll Radiol. 2017; 14: 587-95.
Yang GCH, Fried KO. Pathologic basis of the sonographic differences between thyroid cancer and noninvasive follicular thyroid neoplasm with papillary-like nuclear features. Ultrasonography. 2018; 37: 157-63.
Xu B. Papillary thyroid carcinoma - classic. PathologyOutlines.comonline. Accessed september 2nd, 2025. https://www.pathologyoutlines.com/topic/thyroidpapillaryclassic.html
Baek HJ, Kim DW, Shin GW, Heo YJ, Baek JW, Lee YJ, et al. Ultrasonographic features of papillary thyroid carcinomas according to their subtypes. Front Endocrinol (Lausanne). 2018; 9: 223.
Shin JH. Ultrasonographic imaging of papillary thyroid carcinoma variants. Ultrasonography. 2017; 36: 103-10.
Hekimsoy İ, Ertan Y, Serin G, Karabulut AK, Özbek SS. Comparison of ultrasound findings of papillary thyroid carcinoma subtypes based on the 2022 WHO classification of thyroid neoplasms. Front Endocrinol (Lausanne). 2024; 15: 1434787.
Li W, Wang Y, Gao L, Feng R, Lv K, Wu X, et al. Sonographic characteristics of diffuse sclerosing variant of papillary thyroid carcinoma with histopathological correlation: a preliminary study. Orphanet J Rare Dis. 2024; 19: 136.
Wei S. Follicular thyroid carcinoma. PathologyOutlines.com online. Accessed september 2nd, 2025. Available from https://www.pathologyoutlines.com/topic/thyroidfollicular.html
Ramos Santillan V, Master SR, Menon G, Burns B. Medullary thyroid cancer. [Updated 2024]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025.
Zhao ZL, Wang SR, Kuo J, Çekiç B, Liang L, Ghazi HA, et al. 2024 International Expert Consensus on US-guided thermal ablation for T1N0M0 papillary thyroid cancer. Radiology. 2025; 315: e240347.
